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CoGenesis® AD
阿茲海默症是最常見的認知障礙形式。根據世衛數據，阿茲海默症佔認知障礙個案的60-70%。
認知障礙症狀會在部份長者身上出現，但不是正常衰老的一部份。其中，有5%的病例屬於早發性阿茲海默症。了解阿茲海默症的基因變異有助評估早發或晚發性阿茲海默症的遺傳風險。
根據文獻，約35-60%的早發性阿茲海默症患者擁有家族病史。
Porter, T., Gozt, A.K., Mastaglia, F.L. and Laws, S.M. (2019). The Role of Genetics in Alzheimer's Disease and Parkinson's Disease. In Neurodegeneration and Alzheimer's Disease.
若擁有一組APOE4基因變異會比其他患者多2至3倍風險；若擁有兩組該基因變異發病的風險將會增加到10至15倍。
Van Cauwenberghe, C., Van Broeckhoven, C. & Sleegers, K. The genetic landscape of Alzheimer disease: clinical implications and perspectives. Genet Med 18, 421–430 (2016).
The testing options are as follows:
CoGenesis® Alzheimer's Disease (AD)
- The CoGenesis® AD test covers 6 high-risk genes associated with early-onset Alzheimer's disease. It is specifically designed for individuals already diagnosed with early-onset Alzheimer's disease, those who suspect they may have early-onset AD, or individuals with family members affected by early-onset AD.
CoGenesis® APOE
- The CoGenesis® APOE Genetic Test only covers the APOE gene, a high-risk gene associated with late-onset Alzheimer's disease. It is specifically designed for individuals already diagnosed with late-onset AD, those who suspect they may have late-onset AD, or individuals with family members affected by late-onset AD.
- If you wish to order the CoGenesis® APOE, please visit the product page provided.
- Understanding genetic variations in Alzheimer's disease through our testing results can help assess the inherited risk of early-onset or late-onset Alzheimer's disease.
- Knowing the possible disease-causing genes can assist doctors in formulating personalized treatments. Different genetic variations can affect the efficacy and safety of medications. For example, individuals with the APOE4 genetic variant may have a risk of brain swelling when taking the new drug Aducanumab.
- Approximately 50% of early-onset Alzheimer's disease patients have a family history of the disease. Therefore, individuals with family members affected by Alzheimer's should consider whether they have a chance of carrying genetic variations associated with a high risk of Alzheimer's disease.
- APP, PSEN1, PSEN2, APOE, TREM2, MAPT
After your order is confirmed in the system, the saliva collection kit will be shipped to the address you provided using SF Express within two to three working days.
If you choose to collect saliva at home:
You will receive a saliva collection kit with instructions. Please follow the instructions to collect an adequate amount of saliva to ensure the sample meets the quality standards for testing. For detailed information, please refer to the saliva sampling steps and guidelines.
If you choose to have blood drawn and submit a blood sample at the Hong Kong Health Check Center:
During the order confirmation process, the system will provide available appointment slots at different branches of the Hong Kong Health Screening Center. We will make a reservation for you based on your selected branch and time slot. If the chosen branch or time slot is not available for booking, our customer service representative will contact you to arrange an alternative branch or time slot.
On the day of the scheduled blood draw, please bring your original identification documents to the designated branch of the Hong Kong Health Screening Center for registration. The staff will assist you with the blood draw procedure.
After the blood draw is completed, our staff will collect the blood sample at the Hong Kong Health Screening Center branch and transport it to our laboratory. Please do not attempt to take the blood sample out of the Hong Kong Health Screening Center on your own.
Once our laboratory receives and confirms the quality of your saliva or blood sample meets the testing standards, you will receive an email notification, and you can track the testing progress on this online platform.
- Once our laboratory receives your saliva or blood sample and confirms that the sample meets the quality standards for testing, you will receive an email notification. You can also track the progress of the testing on this online platform. The estimated time for the report will be counted from the point when the sample meets the testing standards.
- The expected turnaround time for this test is 4 working weeks.
- Once your test report is ready, you will receive an email notification. The report is usually delivered electronically on this online platform, where you can log in to view and download it. If you have any specific requirements for delivery, please contact our customer service representative after placing the order.
